Fenerbahçe have the opportunity to move into first place with Galatasaray slipping up, but will have to overcome an in-form Bursaspor side first.
The Istanbul are currently two points behind league leaders Beşiktaş but have a game in hand.
Fenerhbaçe have the second best home record in the league after Trabzonspor but Bursaspor have been performing well under the command of Şenol Güneş.
Fenerbahçe will be without Raul Meireles due to injury while Bursaspor will be without Renato Civelli in defence.
The Yellow Canaries are undefeated in 13 meetings with Bursaspor in the league and the last time Bursaspor beat the Istanbul giants away was back in 2010.
FENERBAHÇE – BURSASPOR
STADIUM: Şükrü Saracoğlu
REFEREE: Hüseyin Göçek
KICK-OFF: 20:00 GMT
FENERBAHÇE: Volkan, Gökhan, Alves, Bekir, Caner, Mehmet Topal, Emre, Alper, Emenike, Webo, Sow
MANAGER: İsmail Kartal
BURSASPOR: Harun, Şener, Serdar Aziz, Şamil, Aziz Eraltay, Belluschi, Ozan, Josue, Volkan, Emre, Fernandao
MANAGER: Şenol Güneş