Fenerbahce will be hoping to build upon a rich vein of form that has seen them book a place in the Europa League Last 16, beat Besiktas in the Istanbul derby and book a place in the Turkish Cup semi-final.
The Yellow Canaries are currently first in the Super Lig but second placed Besiktas will overtake them if they win their game in hand.
Fenerbahce cannot afford to drop any more points but will have to make do without first-choice left-back Caner Erkin and Bruno Alves.
Akhisar meanwhile are not in the best of form having won just two of their last nine games and will be without key defender Douglao as well as Sami while Hugo Rodallega is a doubt.
Fenerbahce are undefeated in 16 of their last 17 league games and have a great defensive record on the road having kept six clean sheets away from home this season.
The Yellow Canaries are in high spirits and it really is difficult seeing Akhisar even getting a point here.
Prediction: Fenerbahce Win
AKHİSAR BELEDİYESPOR – FENERBAHÇE
Stadium: Manisa 19 Mayıs
Referee: Hüseyin Göçek
Kick-Off: 17:00 GMT
Akhsiar: Lukac, Ahmet Cebe, İsmail, Caner, Kadir, Muğdat, Merter, Custodio, Onur, N’Guemo, Rodallega.
Manager: Cihat Arslan
Fenerbahce: Volkan Demirel, Gökhan, Kjaer, Kadlec, Hasan Ali, Mehmet Topal, De Souza, Diego, Alper, Volkan Şen, Van Persie.
Manager: Vitor Pereira