Arsenal boss Arsene Wenger made a few surprise decisions in his starting line-up going into the clash against Hull City at Drayton Park.
Theo Walcott has returned from a knee-injury that ruled him out of the 1-1 draw against PSG in the Champions League mid-week and will start.
Coquelin will replace summer signing Granit Xhaka upfront but Santi Cazorla will keep his place in central midfield.
Germany international of Turkish origin Mesut Ozil will keep his place in the team and will be joined in the attacking third along with Iwobi, Alexis Sanchez up-front and Walcott out wide.
Sanchez has kept his place up-front, meanwhile Olivier Giroud and recent arrival Perez will be on the bench.
Arsenal confirmed line-ups: Cech, Mustafi, Kosciely, Bellerin, Monreal, Coquelin, Cazorla, Walcott, Ozil, Iwobi, Alexis