Arsenal take on Watford at the Emirates hoping to close the gap with Premier League leaders Leicester City to eight points.
Gunners boss Arsene Wenger could welcome back injured goalkeeper Petr Cech but will be without Jack Wilshere, Tomas Rosicky, Alex Oxlade-Chamberlain, Santi Cazorla, Mathieu Flamini and Aaron Ramsey.
Mesut Ozil has recovered from the ankle injury he sustained in the victory over Everton last week and played international football mid-week against England and Italy.
Ozil is expected to start but tiredness could be a factor after playing two games within the space of a week.
Watford have not beat Arsenal on the road since 1998 and have never beat the Gunners at the Emirates.
Arsenal v Watford
Stadium: Emirates
Kick-Off: 15:00 GMT
Arsenal possible starting lineup:
Cech; Bellerin, Gabriel, Koscielny, Monreal; Elneny, Coquelin, Sanchez, Ozil, Welbeck; Giroud
Manager: Arsene Wenger
Watford possible starting lineup:
Gomes; Nyom, Cathcart, Britos, Ake; Jurado, Amrabat, Suarez, Capoue; Deeney, Ighalo
Manager: Quique Sánchez Flores
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