Galatasaray take on Astana at the Türk Telekom Arena needing just a draw to take them to the Europa League Round of 32.
The Lions cannot book a place in the Champions League Last 16 and neither can Astana who are currently last place in Group C just one point behind Galatasaray.
The Istanbul giants will be without long term absentee Hamit Altıntop but Carole and on-loan Manchester City defender Jason Denayer are also out.
Captain Selçuk İnan is a doubt as is experienced defender Hakan Balta.
The visitors have no injuries or suspensions going into the Galatasaray clash but are yet to record an away point in the competition this season.
Galatasaray v Astana
Stadium: Türk Telekom Arena
Galatasaray: Muslera; Sabri Sarıoğlu, Semih Kaya, Chedjou, Hakan Balta; Selçuk İnan, Bilal Kısa; Podolski, Sneijder, Yasin Öztekin; Burak Yılmaz
Out: Hamit Altıntop (knee), Carole (hamstring), Denayer (knee)
Doubtful: Selçuk İnan (metatarsal & flu), Hakan Balta (rib)
Astana: Erić; Ilić, Postnikov, Aničić, Shomko; Maksimović, Cañas, Dzholchiyev, Twumasi, Kéthévoama; Kabananga.