Kasımpaşa take on Fenerbahçe at the Recep Tayyip Erdoğan stadium hoping to overtake their Istanbul rivals and move into joint first place alongside Beşiktaş.
Fenerbahçe manager Vitor Pereira has decided to play Mehmet Topal and Michal Kadlec in defence following injuries to Simon Kjaer, Ba and Bruno Alves.
Ozan Tufan makes his first start for the Yellow Canaries in central midfield alongside Josef De Souza and Raul Meireles.
Former Manchester United duo Luis Nani and Robin van Persie will both start while Fernandao will lead the forward line up-front.
Kasımpaşa boss Rıza Çalımbay makes no major changes going into the game. On-loan Chelsea defender has started every game for Kasımpaşa this season and has helped his side keep the best defensive record in the league. The Istanbul minnows have conceded just one goal this season.
Stadium: Recep Tayyip Erdoğan
Referee: Deniz Ateş Bitnel
Kick-Off: 19:00 GMT
KASIMPAŞA: Isaksson, Veysel, Omeruo, Titi, Bozhikov, Tunay, Donk, Castro, Aydın Yılmaz, Scarione, Eren Derdiyok
MANAGER: Rıza Çalımbay
FENERBAHÇE: Volkan Demirel, Şener, Mehmet Topal, Kadlec, Caner, Ozan, Josef, Meireles, Nani, Van Persie, Fernandao
MANAGER: Vitor Pereria