Eskişehirspor host Beşiktaş at the Atatürk stadium hoping to turn around a dismal start to the season.
Beşiktaş on the other hand will move into first place overtaking reigning league champions Galatasaray with a win against EsEs.
Black Eagles head coach Şenol Güneş has decided to field a similar side to the one that beat Fenerbahçe 3-2 in the Istanbul derby next week.
Tosic returns to the team after missing the midweek Europa league game while Özyakup replaces Necip Uysal in central midfield.
Ricardo Quaresma will keep his place in the team after starting his first game against Sporting in the 1-1 draw against the Portuguese giants on Thursday.
ESKİŞEHİRSPOR – BEŞİKTAŞ
Referee: Deniz Ateş Bitnel
Kick-Off: 17:00 (Local time)
ESKİŞEHİRSPOR: Boffin, Kamil, Birol, Sezgin, Özgür, Ben Khalifa, Toko, Onur, Engin, Defederico, Gekas
MANAGER: Michael Skibbe
BEŞİKTAŞ: Tolga Zengin, Beck, Rhodolfo, Ersan Gülüm, Tosic, Atiba, Oğuzhan, Gökhan, Querasma, Sosa, Gomez
MANAGER: Şenol Güneş