Galatasaray take on Fenerbahçe at the Şükrü Saracoğlu stadium hoping to break their winless away streak which stretches back to the turn of the millennium.
Fenerbahçe are expected to have a full strength side with both Lazar Markovic and Luis Nani having recovered from injury.
Former Manchester United striker Robin van Persie is also expected to start after scoring the winning goal against Kayserispor last week.
Galatasaray also have a full strength squad to chose from but Umut Bulut may get the nod upfront ahead of Burak Yılmaz who only recently recovered from injury.
Lions boss Hamza Hamzaoğlu is likely to field a similar side to the one that beat Benfica 2-1 in the Champions League last week.
Stadium: Şükrü Saracoğlu Stadyumu
Referee: Fırat Aydınus
Kick-Off: 19.00 (Local Time)
FENERBAHÇE: Volkan, Gökhan Gönül, Ba, Kjaer, Caner, Mehmet Topal, Josef de Souza, Diego, Markovic, Nani, Van Persie
MANAGER: Vitor Pereira
GALATASARAY: Muslera, Sabri, Chedjou, Hakan Balta, Carole, Selçuk, Bilal, Jose, Podolski, Sneijder, Umut
MANAGER: Hamza Hamzaoğlu