Liverpool star Emre Can is likely to start in midfield alongside James Milner and Lucas Leiva following injury to Jordan Henderson.
Can made his international debut last week against Poland which ended in a 3-1 victory to Germany.
The 21-year-old played the 90 minutes and was also in the starting line-up against Scotland in the following Euro 2016 Group D qualification game.
The young midfielder was however, deployed as a right-back for Germany. Can is expected to be used a midfielder for Liverpool but Reds boss Brendan Rodgers has also used him as a defender in the past.
Liverpool will be without Philippe Coutinho who was sent off against West Ham in the Reds first home loss to the Hammers since 1963.
West Ham beat Liverpool 3-0 in their last Premier League game before the international break.
Manchester United expected starting line-up: (4-2-3-1): De Gea, Darmian, Smalling, Blind, Shaw, Schneiderlin, Schweinsteiger, Mata, Herrera, Depay, Rooney
Liverpool expected starting line-up (4-3-3): Mignolet, Clyne, Skrtel, Lovren, Gomez, Can, Lucas, Milner, Firmino, Ibe, Benteke