Liverpool take on Roma at the St. Louis’ 47,000-capacity Busch Stadium. as part of their pre-season US summer tour.
Emre Can will start for the Reds after an extended summer break following his Euro 2016 duties for the Germany national team.
The Germany international of Turkish origin was on holiday in Turkey and the US before joining up with his teammates last week.
Reds summer signings Wijnaldum and Sadio Mane will also both start for the Reds.
Lazar Markovic who spent last season on loan at Fenerbahce is on the bench an star striker Daniel Sturridge starts.
First team regulars James Milner and Firminho will also start for Jurgen Klopp’s side.
Liverpool v Roma
Stadium: Busch Stadium
Kick-Off: 01:30 GMT
Liverpool confirmed starting lineup (4-3-2-1 formation): Manninger, Clyne, Lovren, Klavan, Milner, Can, Wijnaldum, Ojo, Mane, Firmino, Sturridge
Subs: Mignolet, Benteke, Coutinho, Henderson, Moreno, Lallana, Brannagan, Ings, Stewart, Wisdom, Markovic, Randall, Alexander-Arnold, George
Manager: Jurgen Klopp