Arsenal take on Ludogorets knowing that a victory would book them a place in the next round of the Champions League.
The Gunners beat the Bulgarian giants 6-0 at the Emirates but will be without Theo Walcott, Hector Bellerin, Nacho Monreal and Santi Cazorla are all out.
Arsene Wenger has decided to start with Olivier Giroud upfront following his brace against West Brom over the weekend.
Alexis Sanchez who had filled in for Giroud during his time out injured will move to the wing with Aarson Ramsey on the other flank and Germany international of Turkish origin Mesut Ozil playing his usual No. 10 role.
Both Ramsey and Giroud returned from a long period out on the sidelines in the victory over Sunderland over the weekend and this will be their first start since making their comeback.
Arsenal come into tonights encounter unbeaten in their last 12 games and will remain at the top of Group A with a victory over the Bulgarian side.
Arsenal Confirmed line-up: Ospina, Jenkinson, Mustafi, Koscielny, Gibbs, Coquelin, Xhaka, Ramsey, Ozil, Alexis, Giroud
Ludogorets Confirmed line-up: Stoyanov; Moti, Minev, Palomino, Pimienta; Dyakov, Anicet, Wanderson, Marcelino, Misidjan; Cafu