Arsenal take on Manchester United at Old Trafford hoping to close the gap with second placed Manchester City.
The North London based club are currently third but will have to be careful as the Red Devils could leapfrog the Gunners with a win.
Arsenal will be without Arteta, Welbeck, Debuchy and Oxlade-Chamberlain but Mesut Özil will be available and is set to make his 29th appearance this season.
Manchester United v Arsenal
Stadium: Old Trafford
Referee: M Dean
Kick-Off: 16:00 GMT
Manchester United: De Gea, Valencia, Jones, Smalling, Rojo, Mata, Blind, Herrera, Young, Fellaini, Falcao
Subs: Valdes, Blackett, McNair, Di Maria, Januzaj, Van Persie, Wilson
Manager: Louis Van Gaal
Injured: Rooney, Shaw
Arsenal: Ospina, Bellerin, Mertesacker, Koscielny, Monreal, Coquelin, Cazorla, Ramsey, Ozil, Alexis, Giroud
Subs: Szczesny, Martínez, Chambers, Gibbs, Gabriel, Flamini, Rosicky, Wilshere, Gnabry, Walcott
Manager: Arsene Wenger
Injured: Arteta, Welbeck, Debuchy, Oxlade-Chamberlain