Liverpool take on Rubin Kazan in Russia hoping to build upon their impressive win against Chelsea last week.
The Reds beat Chelsea 3-1 at Stamford Bridge in what was their first win under the stewardship of Jurgen Klopp in the Premier League.
Liverpool drew their previous game against Kazan in the group 1-1 a fortnight ago.
Emre Can has started regularly for the German boss since he replaced Brendan Rodgers as head coach over the last international break.
The 21-year-old is likely to start in midfield for Liverpool but Klopp is also expected to rotate a few players.
Liverpool are currently second in Group B on four points after three games. Leaders Sion take on Bordeaux in the other game in the group.
Rubin Kazan v Liverpool
Referee: Kevin Blom (NED)
Kick-Off: 20:05 GMT
Rubin Kazan possible starting lineup: Ryzhikov; Cotugno, Kverkvelia, Kambolov, Nabiullin; Carlos Eduardo, Ozdoev, Gokdeniz Karadeniz, Georgiev; Devic, Kanunnikov
Liverpool possible starting lineup: Mignolet; Clyne, Skrtel, Lovren, Moreno; Allen, Can, Milner; Firmino, Coutinho; Benteke