Galatasaray crashed out of the Champions League after losing 2-0 against Atletico Madrid at the Vicente Calderon stadium.
The Lions went into the game without a manager following the sacking of Hamza Hamzaoglu and looked a little lost from the get go.
Griezman opened the scoring on 13 minutes making the most of some woeful Galatasaray defending.
The Lions were punished against for their lacklustre display midway through the second half when Griezman doubled the home sides lead.
Galatasaray are out of the Champions League but can still book a place in the Europa League with a third placed finish as long as they get at least a point against Astana in the final group game.