Beşiktaş take on relegation strugglers Karabükspor at the Osmanlı stadium in Ankara.
The Black Eagles are technically at home but have decided to play in Ankara instead of the Atatürk Olympic.
The Istanbul giants actual stadium the İnönü is currently being reconstructed and will not be ready until the summer.
Karabükspor have the worst away record in the league, the Steelers have only picked up six points on their travels all season.
Beşiktaş meanwhile, have the chance to move into first place in the league table with a win.
The Black Eagles are currently in third place, one point behind second placed Fenerbahçe and three behind leaders Galatasaray.
Besiktas – Karabukspor
KICK-OFF: 20:00 (Local Time)
STADIUM: Osmanlı Stadı
REFEREE: Bülent Yıldırım
BEŞİKTAŞ: Cenk, Serdar, Sivok, Ersan, Motta, Gökhan, Sosa, Atiba, Olcay, Mustafa, Demba Ba
MANAGER: Slaven Bilic
KARABÜKSPOR: Waterman, Erdem, Yiğit, Mabiala, Emre, Musa, Hakan, Traore, Furkan, Viola, Fatih
MANAGER: Yılmaz Vural