Galatasaray take on Konyaspor at the Turk Telekom Arena Stadium in the Turkish Cup quarter-final second-leg tie on Thursday.
Lions boss Fatih Terim will have one eye on the Super Lig title race and is expected to rotate his side.
Terim will be without trusted centre-back Jason Denayer.
The Manchester City loanee is out with a hamstring injury and is not expected to return until April.
Koray and Hakan Balta are expected to get rare starts in defense.
January signing Nagatomo is likely to get more playing time to help his settling in process.
The likes of Selcuk Inan, Belhanda and Eren Derdiyok are likely to keep their place in the team.
The first leg ended in a 2-2 draw in Konya. Galatasaray could progress to the next round with a goaless or 1-1 draw.
The winner of the tie will face Akhisar in the semi-finals. The other semi-final will be between Fenerbahce and Besiktas.
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Galatasaray – Konyaspor
Stadium: Türk Telekom
Referee: Ümit Öztürk
Kick-Off: 20:30 (Local Time)
Galatasaray: Carrasso, Linnes, Koray, Hakan, Nagatomo, Selçuk, Donk, Sinan, Belhanda, Yasin, Eren.
Manager: Fatih Terim
Konyaspor: Serkan, Skubic, Ali Turan, Filipovic, Ferhat, Ali Çamdalı, Moke, Ömer Ali, Mehdi, Milosevic, Jahovic.
Manager: Mehmet Özdilek