Arsenal take on Tottenham in the North London Derby but this time around it will be played at Wembley Stadium, not White Hart Lane.
The change in venue could be a good omen for the Gunners who are unbeaten in their last nine games at Wembley.
The North London based outfit have however, failed to beat a top-five side in their last 15 matches.
Spurs meanwhile are undefeated in their last 12 Premier league games at home.
Arsene Wenger was handed a major boost heading into the clash after Petr Cech was passed fit and has made the starting line-up.
Cech was an injury doubt as was Nacho Monreal due to illness but he has also recovered and got the nod.
Danny Welbeck is back in the contention after recovering from a hip injury but will not start.
The attack will be comprised of Pierre-Emerick Aubameyang upfront with Mesut Ozil and Henrikh Mkhitaryan also starting.
The playmaker of Turkish origin has returned from a short break to Istanbul last week and is match fit.
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Alexandre Lacazette has been benched again meaning we will have to wait a bit longer to see the LMAO in action.
Alex Iwobi started against the Toffees last week out wide but has been dropped for Jack Wilshere.
Aaron Ramsey became the 20th Arsenal player to score a hat-trick in the 5-1 win over Everton but has not made the squad against Tottenham.
Ramsey has been dropped for Elneny who comes into the midfield.
Tottenham meanwhile have a full strength team out with star attacking quartet, Eriksen, Dele Alli, Son and Harry Kane all starting.
Lucas Moura will not start against the Gunners but has been included on the bench.
Goalscorer in the 2-2 draw against Liverpool Wanyama also heads into the clash in the match-day squad but will not start.
Tottenham vs Arsenal Confirmed Line-ups
Arsenal XI: Cech, Bellerin, Koscielny, Mustafi, Monreal, Elneny, Xhaka, Wilshere, Ozil, Mkhitaryan, Aubameyang
Subs: Ospina, Chambers, Kolasinac, Maitland-Niles, Iwobi, Welbeck Lacazette
Tottenham XI: Lloris (C), Trippier, Sanchez, Vertonghen, Davies, Dier, Dembele, Eriksen, Dele, Son, Kane
Subs: Vorm, Aurier, Rose, Wanyama, Sissoko, Lamela, Lucas