Arsenal were the first side to beat AC Milan at the San Siro in the Europa League/UEFA Cup since February 2002.
Despite the defeat, the Italian giants have been in impressive form in recent months, especially on the road.
The Rossoneri side have won their last four matches away from home in which they have scored 10 goals without conceding any.
Genaro Gattuso will be missing just two players against Arsenal with Andrea Conti and Ignazio Abate out injured.
Mateo Musacchio will have to be careful as he will be suspended if he picks up another booking.
See More: Scout Report: West Brom Target Okay Yokuslu – The Midfielder Maestro Causing A Storm The Black Sea
No changes are expected to be made from the side that lost 2-0 to Arsenal.
Star playmaker Hakan Calhanolgu is almost certain to keep his place in the side.
The Turkish international has three goals and six assists in all competitions this season.
AC Milan have only lost one game since Christmas and that was in the first leg against Arsenal.
The visitors have won 11 of their last 15 matches but will have to try and overcome a 2-0 aggregate scoreline to progress to the next round.
