Manchester City will be hoping to bounce back from their Champions League exit against Liverpool.
City boss Pep Guardiola has a few injury issues heading into the game including star man Sergio Aguero.
The star striker has is out with a knee injury against Spurs.
Guardiola is also without key midfielder Fernandinho who is suspended for the tie.
Defender John Stones is a doubt due to a thigh problem but has made the squad.
The Citizens are also without left-back Benjamin Mend who has been out since September with knee ligament damage.
Midfielder of Turkish origin Ilkay Gundogan will be available for City after making the squad.
See More: Was Cengiz Under Right To Pick Roma Over Man City?
Gundogan did not start against Liverpool in the Champions League but did come on as a substitute.
Tottenham head into the clash having won their last two home league games against City.
City meanwhile have only won one of their last five Premier League games against the North London based outfit.
The Premier League leaders have lost their last three games in all competitions.
Man City squad: Ederson, Bravo, Danilo, Walker, Otamendi, Kompany, Laporte, Delph, Zinchenko, Toure, Gundogan, D Silva, B Silva, Sterling, Sane, De Bruyne, Foden, Diaz, Jesus
