Arsenal have a few Germany international players among their ranks with Per Mertesacker, Shkodran Mustafi and Mesut Ozil.
Mertesacker and Mustafi did not end up getting called up for the friendly games against Spain and Brazil but Ozil sure did.
The playmaker of Turkish origin is likely to start against Spain in Dusseldorf on Friday according to the official Bundesliga website.
Ozil is one of two Premier League players expected to feature, with Manchester City midfielder Leroy Sane also named in the predicted line up.
Fellow player of Turkish origin Ilkay Gundogan and Emre Can also got called up.
The Liverpool midfielder is unlikely to feature due to a back injury and Gundogan is unlikely to start but could make the matchday squad.
Germany are on a 21-match unbeaten run and won all 10 games in reaching the 2018 FIFA World Cup, becoming only the second team after Spain in 2010 to achieve a 100 per cent qualifying record.
Germany vs Spain
Probable line-ups
Germany: ter Stegen – Kimmich, Hummels, Süle, Hector – Khedira, Kroos – Müller (c), Özil, Sane – Werner
Absentees: Neuer (foot) [not selected: Reus, Götze, Schürrle]
Coach: Joachim Löw
Spain: De Gea – Nacho, Pique, Ramos (c), Alba – Isco, Saul, Iniesta – Silva, Asensio – Costa
Absentees: N/A [not selected: Morata, Sergi, Pedro, Mata, Fabregas, Bartra, Moreno, Martinez, Illarramendi]
Coach: Julen Lopetegui