Borussia Dortmund take on Portuguese giants Benfica in the Champions League Last 16 second-leg tie at the Westfalenstadion stadium.
The Bundesliga outfit face a 1-0 first-leg deficit against Benfica.
Dortmund head into the clash without long-term absentees Sven Bender, Sebastian Rode are out and Mario Gotze has been ruled out indefinitely with a metabolic disorder.
The German giants will also be without Raphael Guerreiro who has a thigh injury.
As expected Politic has replaced Reus and Schmelzer and Durm will start on the wings.
Weigl and Castro have been deployed in central midfield and put on an impressive display in the 6-2 victory over Bayer Leverkusen over the weekend.
Aubameyang will be called upon to provide Dortmund with the much needed goals.
Benfica meanwhile only have one major injury concern in Ljubomir Fejsa who is out.
Turkish international due Nuri Sahin and Emre Mor both miss the tie. Sahin is out with a knee injury while Mor has not been included in the squad.
The Portuguese side are looking to progress to the quarter-finals for the third time in six seasons.
Dortmund vs Benfica: Confirmed Lineups
Borussia Dortmund: Bürki, Bartra, Dembélé, Aubameyang, Pulisic, Sokratis, Piszczek, Castro, Schmelzer, Weigl, Durm
Subs: Weidenfeller, Guerreiro, Schürrle, Kagawa, Merino, Ginter, Passlack
Benfica: Ederson, Luisao, Samaris, Mitroglou, Lindelof, Salvio, Eliseu, Pizzi, Cervi, Almeida, Semedo
