Beşiktaş face a tricky away trip to Serbia where they will face Partizan in their third Europa League Group C game.
Slaven Bilic will be without the injured Mustafa Pektemek, Jose Sosa and Serdar Kurtuluş.
Bilic will welcome back the return of Oğuzhan Özyakup who will be in charge of pulling the creative strings in midfield.
Demba Ba is expected to start upfront, the Senegalese international already has six goals this season and scored a brace on the weekend.
Partizan: Lukac, Stankovic, Vulicevic, Cirkovic ,Volkov, Ilic, Pantic, Zivkovic, Sasa İlic, Grbic, Danko Lazovic
Beşiktaş: Tolga Zengin, İsmail Köybaşı, Ersan Gülüm, Sivok (Franco), Motta, Gökhan Töre, Veli Kavlak, Hutchinson, Oğuzhan Özyakup, Olcay Şahan, Demba Ba.
In the other Group C games Mauricio Pochettino is set to make a number of changes to his side demonstrating the great squad depth he has at his disposal.
On the injury front Kyle Walker remains out after surgery while Kyle Naughton and Nabil Bentaleb are both out with ankle problems.
The Greek side have a clean bill of health going into the game.
Asteras are currently first in Group C with four points, Tottenham are level with Beşiktaş on two points and Partizan are last with just one point.
Tottenham: Vorm, Dier, Vertonghen, Chiriches, Davies, Stambouli, Dembele, Paulinho, Townsend, Lennon, Soldado
Asteras Tripoli: Kosicky, Sankare, Panteliadis, Lluy, Zisopoulos, Rolle, Usero, Munafo, Barrales, Mazza, Gianniotas