Liverpool take on Bournemouth on the back of knocking Premier League leaders out of the Champions League.
The Reds managed to crush City 3-0 at home and then went onto beat the Citizens 2-1 at the Etihad.
The Merseyside based outfit will take on Roma next in the Champions League but they will have to focus on the domestic league until then to guarantee a top-four finish.
Liverpool manager Jurgen Klopp will welcome back captain Jordan Henderson who missed the City clash due to suspension.
Klopp does however, face several injury problems heading into the clash.
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Nathaniel Clyne, Ragnar Klavan, Emre Can (back) and Adam Lallana (muscle problem) are all out.
Can and Lallana were expected to miss the rest of the season but Klopp has hinted they could both return beforehand.
The midfielder of Turkish origin has been a star man for Klopp this season despite his injury problems.
Can has scored a career-high six goals this campaign despite approaching the end of his contract with an extension deal in sight.
Mohamed Salah is match fit and just one goal away from becoming the eighth different player to find the back of the net with 30-plus goals in a single Premier League season.
The Reds head into the game unbeaten in their last 18 Premier League home games, the longest run in the division.
Bournemouth meanwhile have won just two of their 17 games away to top-six opposition.
Liverpool Squad: Karius, Alexander-Arnold, Lovren, Van Dijk, Robertson, Milner, Wijnaldum, Henderson, Oxlade-Chamberlain, Salah, Firmino, Mane, Mignolet, Clyne, Klavan, Masterson, Moreno, Woodburn, Kane, Jones, Ings, Solanke