Liverpool take on Everton at Goodison Park facing a bit of a mini-injury crisis, with a number of players missing out.
Joel Matip will not feature again this season with injury and Ragnar Klavan has also been ruled out of the derby.
Adam Lallana and Joe Gomez are also sidelined for the game.
Jurgen Klopp had further bad news as Emre Can has been ruled out with a back problem that has seen him not play since coming off injured in the 5-0 victory over Watford.
There were reports that the midfielder of Turkish origin could be ruled out for the rest of the season but BBC Sport understand that he could be back before then.
Klopp faces a major headache in the return-leg against Manchester City in the Champions League as Jordan Henderson is suspended and Can is injured.
The Liverpool boss could also be without star man Mohamed Salah who had to be substituted off soon after scoring his 38th goal in the 3-0 win over City.
Klopp has not ruled Salah out but does not seem overly optimistic either.
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“We’ve tried everything to make him available. There are 23 hours to go so let’s see what happens,” Klopp said.
The head coach could call up several academy players as a result, including Curtis Jones, Rafael Camacho, Liam Millar, Herbie Kane, Adam Lewis and Nathaniel Phillips.
Asked about playing youngster in the derby, Klopp said said: “Honestly, yes. If I would say now ‘no’ then they would have played already.
“Why should we do that? They are young, they are good, they are talents. It’s good to be a talent but the next level is another one.
“If I can avoid it I will try not to use them to show we have so much problems. The boys have to sort it. That will not happen as long as I can avoid it.
“But having them around, giving them the feeling that they are closer and closer, which they are, I have no problem with that.”
