Galatasaray take on Karabukspor at the Dr. Necmettin Şeyhoğlu Stadium as Super Lig leaders.
The Lions will have to start winning games on the road if they hope to stay at the top.
The Istanbul giants have lost five of their last six away games including their last two.
Galatasaray cannot afford to keep dropping points away from home considering just three points seperate first from fourth in the league.
The Lions will be without Manchester City loanee Jason Denayer who is out with a hamstring injury.
The Belgium international has missed the league leaders last three Super Lig games.
Denayer is however, expected to return sooner than expected after returning to training this week.
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The 24-year-old could be back for selection by next week.
The visitors will also be without striker Eren Derdiyok but star striker Bafetimbi Gomis who scored a hat-trick in the 5-0 win over Bursaspor last week is available and likely to start.
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Karabukspor vs Galatasaray
Stadium: Dr. Necmettin Şeyhoğlu Stadı
Referee: Mete Kalkavan
Kick-Off: 19:00 (Local Time)
Karabukspor: Çağlar, Hakan Aslantaş, Kravchenko, Özgür Yılmaz, İshak Doğan, Cem Özdemir, Osman Çelik, Kage, Traore, Ibanez, Leandrinho
Manager: Levent Açıkgöz
GALATASARAY: Muslera, Linnes, Maicon, Serdar Aziz, Nagatomo, Selçuk, Donk, Belhanda, Rodrigues, Feghouli, Gomis
TEKNİK DİREKTÖR: Fatih Terim