Besiktas take on Trabzonspor at the Medical Park Stadium on Friday knowing that a win could mark a pivotal point in the title race.
The Black Eagles will make a huge statement if they beat Trabzonspor away just a week after putting Fenerbahce to the sword.
The reigning champions would also move three points clear of fourth-placed Fenerbahce and cut the gap with leaders Galatasaray to just three.
The Istanbul giants will be without Ricardo Quaresma who is suspended and Pepe who is injured.
Jeremain Lens fills in for the Quaresma while Tosic has replaced Pepe.
Vagner Love keeps his place up front and Tolgay Arslan will start ahead of Oguzhan Ozyakup in central midfield.
Benfica loanee Anderson Talisca has also got the nod for the visitors.
Trabzonspor boss Riza Calimbay has decided to leave Yusuf Yazici on the bench but teenage sensation Abdulkadir Omur will start as will in form Turkey international Okay Yokuslu.
See More: Turkish League Previews 24: Can Galatasaray End Their Away Funk? Besiktas Set For Third Derby In A Week
Trabzonspor vs Besiktas
Stadium: Medical Park
Referee: Halis Özkahya
Kick-Off: 20:00 (Local Time)
Trabzonspor: Onur, Pereira, Hubocan, Durica, Novak, Okay, Kucka, Abdülkadir, Sosa, Olcay, N’Doye
Manager: Rıza Çalımbay
Besiktas: Fabri, Gökhan Gönül, Tosic, Medel, Adriano, Atiba, Tolgay, Lens, Talisca, Babel, Love
Manager: Şenol Güneş