Stoke City loanee Badou Ndiaye will return after being suspended for the Match Day 2 defeat away to Porto.
Ndiaye will be match fit heading into the game and is almost certain to start in central midfield alongside Ryan Donk
Terim will also have his sole lone striker Eren Derdiyok back for the game.
With Derdiyok back it will allow Sinan Gumus to move back to his preferred position on the wing with Garry Rodrigues set to start on the opposite flank with Younes Belhanda in an attacking midfield role down the middle.
Galatasaray vs Schalke Predicted Lineups
Stadium: Türk Telekom Stadı
Kick-Off: 22:00 (Local Time)
Referee: Benoit Bastien
Galatasaray: Muslera, Linnes, Maicon , Ozan Kabak Yuto Nagatomo, Ryan Donk, Ndiaye, Sinan Gümüş, Younes Belhanda, Garry Rodrigues, Eren Derdiyok
Manager: Fatih Terim
Schalke: Nübel, Caliguiri, Sane, Nastasic, Mendly, Mascarell, Bentaleb, Uth, Harit, Konoplyanka, Burgstaller
Manager: Domenico Tedesco