Arsenal take on Hull City at Drayton Park hoping to extend their Premier League winning streak to three games.
The Gunners could be without England international Theo Walcott who missed the Champions League clash against PSG mid-week with a knee injury.
Oxlade Chamberlain put on an underwhelming display in the 1-1 draw against PSG and could find himself replaced by summer signing Perez.
Two players who are almost certain to feature are Mesut Ozil and Alexis Sanchez who would be starting for just the second time together this season in the league – following the 3-1 win over Watford.
Arsene Wenger has confirmed that Petr Cech will replace David Ospina in goal. The Colombian international put in an inspired display against PSG mid-week and there were rumours that he could keep his place in the starting line-up.
The Gunners are still without Aaron Ramsey, Gabriel, Carl Jenkinson, Danny Welbeck and Per Mertesacker.
The absence of Gabriel and Mertesacker gives Wenger the simple option of starting Koscielny with summer signing Mustafi. Bellerin and Monreal are likely to start as full-backs for the North London based outfit.
Granit Xhaka and Santi Cazorla are likely to start in central-midfield with Olivier Giroud leading the attack up-front.
Arsenal have won five of their last six away games against Hull City and have scored at least two goals or more in 10 of their last 11 meetings with the Tigers.
The Gunners have been so dominant over Hull in recent years that they have been winning at both half time and full time in their last three visits to Drayton Park.
Hull City v Arsenal
Stadium: Drayton Park
Kick-Off: 15:00 GMT
Arsenal: Cech, Monreal, Koscielny, Mustafi, Bellerín, Xhaka, Cazorla, Sánchez, Özil, Pérez, Giroud.
Hull predicted line-up: Jakupovic, Robertson, Davies, Livermore, Elmohamady, Meyler, Huddlestone, Mason, Diomande, Hernández, Snodgrass.
Arsenal predicted line-up: Cech, Monreal, Koscielny, Mustafi, Bellerín, Xhaka, Cazorla, Sánchez, Özil, Pérez, Giroud.
Guide to pronouncing Mesut Ozil