Chelsea have one in three chance of drawing Turkish giants depending on Liverpool & Tottenham results
Chelsea finished Group C runners up following their 1-1 draw at home to Atletico Madrid on Match Day 6.
The Blues secured a place in the Last 16 draw but cannot face another English side or the winner of their own group – Roma.
Therefore should Liverpool win their respective groups tomorrow the reigning Premier League champions will have a one in three chance of drawing Besiktas.
Chelsea will only be able to draw PSG, Barcelona or Besiktas if the Reds win their respective games.
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PSG, Barcelona and Besiktas have already guaranteed first place in their groups.
Liverpool head into Match Day 6 as group leaders but Sevilla could end up pipping them for the top spot.
The Reds need a point at Spartak to be sure of qualifying or win to secure a first place finish.
Sevilla will qualify if they beat last placed Maribor. If the La Liga side top the group they also have a chance of drawing Chelsea in the next round.
Currently three Premier League sides have secured top spot; Manchester United, Manchester City and Tottenham.
Besiktas meanwhile take on Red Bull Leipzig on Match Day 6 in Germany on Wednesday.
Black Eagles boss Senol Gunes is expected to make several changes and has left Pepe, Babel, Quaresma, Atiba and Tolgay out of the squad.